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Lysosomal processing of TMEM106B yields a C-terminal fragment that binds to v-ATPase 172 and its accessory protein 1 (AP1) component 172 as well as to cathepsin D (CTSD) 179 , one of approximately a dozen proteases in lysosomes that are activated at low pH and collectively are capable of degrading endogenous and internalized exogenous proteins completely to amino acids

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Chen W, Wang D, Ma L, Wu F, Ren Q, Tao J, Chen X, Zhang A (2024) Chronic arsenite exposure induced skeletal muscle atrophy by disrupting angiotensin II-melatonin axis in rats