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Maintaining optimal B12 levels is vital for sustaining brain health and overall mental clarity

The endothelial Nrf2 can be triggered via increased reactive oxygen species production and PI3K-Akt signalling induced by shear stress (Reference Chen, Varner and Rao85)

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Excessive absorption or decreased use of iron in cells leads to an imbalance in iron ion concentrations for various reasons, and this results in iron overload

Generally, persistent M1 macrophage activation causes excessive stimulation of pro-inflammatory cytokines to release, causing an imbalance of colonic homeostasis and barrier disruption (Lv et al., 2021), 1,25-dihydroxyvitamin D3 (Long et al., 2022), loganin (Liu et al., 2020), methyl gallate (Zhou et al., 2022), platycodin D (Guo et al., 2021), triptolide (Tang et al., 2020), and tiliroside (Zhuang et al., 2021) suppresses M1 macrophages activation and promote M2 macrophages, thereby alleviating UC