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While naturally occurring IGF-1 plays a critical role in growth and development, the LR3 modification extends its half-life and dramatically enhances its biological availability making it a favorite for research into athletic performance, muscle rehabilitation, and age-related decline

Nat Rev Endocrinol 3 , 157167 (2007)

Sermorelin is a single GHRH analog that produces a gentler, more physiologic GH pulse often preferred for sleep, gradual anti-aging, and patients new to peptide therapy

The most meaningful differences are how each peptide signals the pituitary, how strong the human evidence is for real outcomes, and whether what youre being offered is FDA-approved, compounded, or research-only (Molitch et al., 2011)

Someone with known heart disease, high blood pressure, previous heart problems or a family history of rhythm issues should take that into account and may need to be more cautious