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Abbreviations ALD: Alcoholic liver disease ANO1: Anoctamin-1 APAP: Acetaminophen ASCs: Adult stem cells CFTR: Cystic fibrosis transmembrane regulator COVID-19: Corona virus disease 2019 DILI: Drug-induced liver injury ESCs: Embryonic stem cells FFA: Free fatty acids GSH: Glutathione HBV: Hepatitis B virus HCV: Hepatitis C virus HEV: Hepatitis E virus HSCHep/HSC: HepaRG cells and hepatic stellate cells iPSC: Induced pluripotent stem cell IRI: Ischemia-reperfusion injury LDL: Low density lipoprotein LT: Liver transplantation NAFLD: Non-alcoholic fatty liver disease NASH: Non-alcoholic steatohepatitis PHHs: Primary human hepatocytes ROS: Reactive oxygen species SARS-CoV-2: Severe acute respiratory syndrome coronavirus 2 SHs: Small hepatocytes TNF: Tumor necrosis factor 2D: 2-Dimensional 3D: 3-dimensional References Asrani, S

AD Shown are representative western blotting and quantification of Nrf2, GPX4, and PTGS2

Statistical analysis Statistical analysis was performed using GraphPad Prism ( We employed a standard two-tailed unpaired Students t-test or one-way ANOVA for calculations

Aged cheeses, sauerkraut, kimchi, kombucha, and aged meats can trigger histamine symptoms (headaches, flushing, digestive upset, sleep disruption) in this population