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Several studies highlighted that induction of HO-1 is triggered by its substrate heme as well as by biological, chemical, and physiological stress conditions brought on by toxic concentrations of drugs or metals, and consequently, the relief of the stress condition can downregulate the HO-1 levels again [83]

the single controlled insomnia trial most often cited showed modest effects at best

The MCH bacterial group showed a significant decrease compared to the control (74.03 1.270 Vs 108.6 2.452, P = 0.0072**), also the 1st group showed a significant decrease compared with the control (61.57 2.194 Vs 108.6 2.452, P = 0.0097**), the 2nd injection group showed nonsignificant increased compared to control (160.4 13.35 Vs 108.6 2.452, P = 0.0686), also the Vacc + Bac showed non-significant decreased (68.87 10.35 Vs 108.6 2.452, P = 0.0638), the 1st injection showed non-significant decreased comparing with bacteria (61.57 2.194 Vs 74.03 1.270, P = 0.0581), while the 2nd injection showed significantly increased compared with a bacterial group (160.4 13.35 Vs 74.03 1.270, P = 0.0198*), furthermore the Vacc + Bac showed non-markedly decreased comparing with a bacterial group (68.87 10.35 Vs 74.03 1.270, P = 0.8478) (Fig

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