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Kynurenine (Kyn), primarily produced by fibroblasts, activates AhR, induces PTEN expression, and suppresses AKT/mTOR signaling, thereby reducing fibroblast migration and activation [117]

Moreover, the extract maintained the antioxidant defense, preserving the levels of reduced glutathione and protein thiol ( Conclusion In conclusion, it was showed for the first time that the pretreatment with Ab aqueous extract was able to increase the survival of septic animals by a mechanism involving immunomodulatory and antioxidant protective effects as summarized in Figure 6

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Zhou J, Goldsbrough PB: An Arabidopsis gene with homology to glutathione S-transferases is regulated by ethylene

As with most antioxidants, glutathione is essential to a healthy gut, and therefore, an optimal immune system