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Carotenoids Carotenoids, such as lycopene, -carotene, xanthophyll, lutein, and zeaxanthin, are lipophilic antioxidants capable of detoxifying various ROS and most effectively capture the lipid peroxyl radical (LOO ), thus providing membrane protection

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Although biotransformation reactions take place within cytoplasm and mitochondria but they mostly happen within endoplasmic reticulum (E.R)

Disclosures: Yan Han: Nothing to Disclose, Zhiwei Chen: Nothing to Disclose, Jing Tang: Nothing to Disclose, Na Wu: Nothing to Disclose, Hong Ren: Nothing to Disclose 1950 INCREASED PD-1+TIGIT+TIM-3+ IN PERIPHERAL CIRCULATING CELLS PREDICTS OUTCOMES AND TREATMENT RESPONSE IN HCC PATIENTS WITH TRANSARTERIAL CHEMOEMBOLIZATION Xiaoli Liu 1 Huiwen Yan 1 Lihua Yu 1 Yixin Hou 1 Tingting Jiang 1 Xianbo Wang 1 Jiang Yuyong 1 Yaxian Kong 2 Zhiyun Yang 1 , 1 Capital Medical University Affiliated Beijing Ditan Hospital, 2 Institute of Infectious Diseases, Beijing Ditan Hospital Background: Transarterial chemoembolization (TACE) is an important treatment option for patients with unresectable hepatocellular carcinoma (HCC) and good liver function

Commonly reported side effects remain mild and often transient