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Discussion This work uncovers a previously unappreciated role for BDNF-TrkB signalling in regulating cellular metabolic pathways, such as glutathioneascorbate and energy metabolism

During ischemia, oxygen deprivation suppresses critical metabolic pathways such as those involving fatty acids, ketone bodies, branched-chain amino acids (BCAAs), and glucose oxidation, drastically reducing ATP production

Cell Cycle 15(11):14621470

Conversely, oral GSH administration significantly alleviated glutamine accumulation (Figure 2H)

Furthermore, mutations in mitochondrial and nuclear genes encoding proteins that are required for proper assembly and stability of the mitochondrial respiratory complex also lead to complex I deficiency