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Wes-Kucharska D, Rokicki D, Jezela-Stanek A (2021) Epilepsy in mitochondrial diseasescurrent state of knowledge on aetiology and treatment

Previous studies show that this phenotype switch is mainly related to the metabolic reprogramming per se (11, 12)

Nitric oxide synthase is present in the cerebrospinal fluid of patients with active multiple sclerosis and is associated with increases in cerebrospinal fluid protein nitrotyrosine and S-nitrosothiols and with changes in glutathione levels

The previous studies provide strong evidence that iron accumulation is closely involved in the pathological process of secondary injury of TBI, and maintaining iron homeostasis is an effective means against ferroptosis triggered by TBI [49]