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A randomized, double-blinded, placebo-controlled trial showed that 20 mg of melatonin for breast cancer before and during the first cycle of adjuvant chemotherapy modulated serum levels of brain-derived neurotrophic factor (BDNF) and its receptor tropomyosin kinase B (TrkB), suggesting a neuroprotective effect of melatonin [57]

Both offer benefits for athletes, but NAC is often preferred due to its extensive research in exercise recovery, cost-effectiveness for daily use, and additional respiratory support benefits