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[0332] The binding specificity of monoclonal antibodies or portions thereof that bind ALPP and/or ALPPL2, preferably binding the epitope bound by one or more of M25ADLF, M25ADLFEG, M25ADLFDS, M25FYIA, M25FYIAEG, M25FYIADS, M25, M25EG, M25DS, M25AELF, M25AELFEG, M25AELFDS, M25ADL99P, M25ADL99G, M25ADS95R, M25ADD28G, M25ADS91G, M25ADY93H, M25ADYHSRLF, M25GRITSGFYGDwtLC, M25FSITSGFYGDwtLC, M253018IA, M253018LF, M25AD, M25ADX, ALPPL2rd3_l, ALPPL2rd3_2, M25AGIA, M25AGLF, M25ASIA, M25ASLF, M25 ASwt, M25 AVIA, M25AVLF, M25 ALIA, M25ALLF, M25wtIA, and/or M25wtLF can be prepared using any technique including those disclosed here, can be determined by immunoprecipitation or by an in vitro binding assay, such as radioimmunoassay (RIA) or enzyme-linked immunoabsorbent assay (ELISA)

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