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Downstream signaling involves PI3K/AKT, MAPK/ERK, and PLC- pathways, which are well-characterized drivers of synaptogenesis, dendritic spine maturation, and neuronal survival

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Within research settings, this peptide combination is utilized to examine interaction profiles, receptor engagement patterns, and downstream signaling responses when two distinct peptide structures are present simultaneously

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Van HMJ, Taig R, Kuppens J, Torao JS, Moret EE, Parsons RB, Sartini D, Emanuelli M, Martin NI (2017) Inhibitors of nicotinamide N -methyltransferase designed to mimic the methylation reaction transition state