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NFkB pathway is the major pathway of inflammation

Propranolol inhibits 5'-monodeiodinase that converts L-thyroxine (T4) to triiodothyronine (T3) , lowering T3 levels by ~30%

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Some of the cholesterol-independent effects of are believed to be mediated by inhibition of isoprenoids, which serve as lipid attachments for intracellular signaling molecules including small GTP-binding proteins, Rho, Ras, and Rac (Liao & Laufs, 2005)