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Increased presence of markers of oxidative stress has been found in the spinal cord and other biological fluids (such as plasma and cerebrospinal fluid) of ALS patients, together with increased expression of NOX2 enzyme

Akgedik, R

Such precision medicine approaches are contingent upon robust diagnostic and prognostic tools that can guide patient stratification, define optimal therapeutic windows, and serve as pharmacodynamic endpoints

If the diagnostic injection is in the psoas tendon bursa, it should be done independently of a hip joint injection

In mice, Anakinra (IL1Ra) improved performance on cognitive tasks (203) but other experimentations could not confirm these findings (204)