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Overall, data support that intermediate filaments IFD-1 and IFD-2 concentrate into juxtanuclear foci, the dimensions of which can increase under proteostress

Abstract In spite of the introduction of cancer immunotherapy for improving tumor suppression, the modality of this revolutionary treatment has faced a number of challenges because of immune evasion, poor tumor immunogenicity, and resistance in solid tumors

It also plays a role in nerve impulse transmission and neurotransmitter synthesis

A computational screen for regulators of oxidative phosphorylation implicates SLIRP in mitochondrial RNA homeostasis

Our work is supported by National Natural Science Foundation of China (NSFC) #82205069 awarded to CZ