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Pangrazzi L, Balasco L, Bozzi Y

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NCI Thoracic Malignancy Steering Committee Meeting

Indo-1 fluorescence signals were measured at 2 h after treatment with PMA (100 nM) and in the presence of the agonists targeting TRPV2 (CBD, 5 M), TRPC3 (GSK1702934A, 100 M), TRPV4 (GSK1016790A, 100 nM), Piezo1 (Yoda1, 10 M) ( n = 3)

In summary, although the two neurons did not die of GPX4 reduction, the study focused on only one point of GPX4 and did not delve into other regulators, indicating that there are other pathways affecting the activity of POMC neurons under obesity conditions (129)