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These cytokines include IFN-, which plays a key role in tumor control, upregulates the immune response, and exerts a pro-inflammatory activity on immune infiltration and tumor cells ( + T cell inhibition ( Figure 3 )

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This resistance is mediated by different causes and mechanisms, (that are resumed in Table 1 and excellently summarized in different review articles [78].One of the most obvious and intriguing mechanisms of resistance involves alteration in CD38 expression, a crucial factor in both primary and acquired resistance to anti-CD38 therapies

doi: 10.1093/intimm/13.4.397 5 MalavasiFDeaglioSFunaroAFerreroEHorensteinALOrtolanEet al