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The ability to regulate sensory input by filtering out irrelevant stimuli (to prevent sensory overflow) can also be enhanced by opioid agonists, as suggested by a study where a low dose of morphine (10 mg PO) in 18 males enhanced modulation of the startle reflex to a noise burst following a prestimulus, a phenomenon called prepulse inhibition (Quednow et al., 2008)

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Takahashi M, Dor S, Ferris CD et al (2000) Amyloid precursor proteins inhibit heme oxygenase activity and augment neurotoxicity in Alzheimers disease