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Daratumumab (Janssen Pharmaceuticals) is the first high-affinity CD38-targeting Ab to be approved by the FDA and EMA as a monotherapy for relapsed/refractory MM (RRMM) [65]

The critical importance of sourcing Quality, safety, and efficacy of the product depend heavily on where they come from

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Allergic Reactions: Rare, but monitor for rash, urticaria, or anaphylaxis

Critically, the study documented no significant changes in oral glucose tolerance tests, no alterations in fasting insulin levels, and no changes in serum IGF-1 concentrations across all treatment groups