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Briefly, cells were incubated with 10 M EdU for 1 h

Two of the three compounds have zero meaningful human trial data

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Iron activates NF-B in microglia which triggers the production of pro-inflammatory cytokines, including NO

Owing to their high intracellular abundance, they also serve as indicators of compromised cellular integrity: once released extracellularly, HSP70s act as damage-associated molecular patterns (DAMPs), triggering immune responses through receptors such as the toll-like receptors TLR2 and TLR4 (Theivanthiran et al., 2022