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Pemetrexed can cause severe, and sometimes fatal, renal toxicity

However, transporter involvement in physiologically relevant BBB models remains to be mechanistically confirmed, warranting further validation in mammalian systems

Low consumption of B12 can lead to deficiency, where B12 levels become too low to meet the bodys needs

It should not be used in patients with cobalt or cyanocobalamin allergy

Nevertheless, his case is sometimes cited as an example of vitamin B12 deficiency and how severe it can get with time, if left untreated, it can lead to serious health issues, including neurological symptoms like dementia