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Furthermore, inhibiting iron response element binding protein 2 (IREB2) using shRNA changes the expression of various iron genes (e.g., TRFC, FTH1, and FTL), affecting iron absorption, metabolism, and storage (80, 81)

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Quinolinic acid potentially links kidney injury to brain toxicity

The fecal samples of UC patients were different from those of healthy volunteers in principal coordinate analysis (PCoA) and principal component analysis (PCA). The relative abundances of g Roseburia and g-Lachnospiraceae ND3007 group were greater in healthy volunteers than in UC patients, but o-Lactobacillales abundance exhibited the reverse tendency, according to a linear discriminant analysis effect size (LEfSe) analysis. The abundances of the g-Eubacterium halli group and g-Lachnospiraceae ND3007 group were greater in the healthy volunteers than in the UC patients (P 0.05) according to the Wilcoxon rank-sum test bar plot