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hence, many providers suggest repeating infusions periodically

Step 2: tert-butyl 4-(6-bromopyridin-3-yl-2,4,5-d 3 )piperazine-l-carboxylate A solution of tert-Butyl 4-(pyridin-3-yl-d 4 )piperazine-l-carboxylate (200 mg, 0.75 mmol) in 20 mL of acetonitrile was cooled in an ice bath before a solution of N- bromosuccinimide ( 120 mg, 0.67 mmol) in 5 mL of acetonitrile was added over a period of 10 minutes

One of the main challenges in developing safe and effective antibody-drug conjugates is the generation of suitable chemical linkers between cytotoxic drugs and monoclonal antibodies

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