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Aldehydes such as formaldehyde generate reactive oxygen species (ROS) through their heating and vaporisation and cause inflammation in the lungs

Studies in Caenorhabditis elegans have shown that the reciprocal regulation of CDF-2 (a ZnT-like importer) and ZIPT-2.3 (a ZIP-like exporter) on lysosome-related organelles mediates zinc storage during excess and release during deficiency, demonstrating a conserved directional flow of zinc 102

More evidence exists that a single subunit, specifically homomeric receptors, can form functional channels, such as 7, 8, and 9

For example, 6 subunit is exclusively expressed in cerebellar granule cells and the subunit is largely restricted to the retina

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