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Removing pyruvate in the media prevents the recycling of NADH into NAD + by the cytosolic LDH enzyme, forcing mitochondrial redox shuttle systems to support cytosolic redox balance 18

Accordingly, we speculated that there is a complex link between ferroptosis and inflammation in psoriatic lesions

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At physiological pH (approximately 7.4), the side-chain -amino group is protonated to form -NH 3 + , conferring a net positive charge on the molecule

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