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Sensitive and specific multi-cancer detection and localization using methylation signatures in cell-free DNA

doi: 10.1136/THORAX.58.2.175 97 van der VlietAEiserichJPShigenagaMKCrossCE

Urolithin A, a natural metabolite derived from ellagitannins, stimulates mitophagy through pathways such as PTEN induced kinase 1 (PINK1)/Parkin RBR E3 ubiquitin protein ligase (PRKN), leading to improved mitochondrial health and enhanced muscle function

S.Tiwari-WoodruffS

451,452 Activation of mTORC1 by tumor-derived lactate leads to TFEB retention in the cytoplasm, which in turn decreases the expression of the macrophage-specific vacuolar ATPase subunit ATP6V0d2, which is required for lysosomal-mediated degradation of hypoxia-induced factor 2 (HIF-2)