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Phase 2 trials (Jastreboff et al., NEJM, 2023) have shown it to be highly effective for weight reduction in adults with obesity

In POTS, this signaling fails, leading to blood pooling in the lower extremities and a rapid, compensatory spike in heart rate

8,25,26 From a cost-effective public health standpoint, some might advocate widespread oral vitamin B 12 supplementation without laboratory testing to provide insurance against subclinical B 12 deficiency

"The risk of lactic acidosis increases with the degree of renal dysfunction and the patient's age." U.S

Conclusion Undereye dark circles are multifactorial, with both clinical and non-clinical elements contributing to their development