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Side effects are rare but can include mild discomfort or allergic reactions

Spatiotemporally distinct roles of cyclooxygenase-1 and cyclooxygenase-2 at fetomaternal interface in mice

it is naturally occurring, nontoxic, and is active at a very low nanomolar concentration.11 Another piece of research described GHK-Cu as a safe, inexpensive, extensively studied compound.3 These conclusions primarily apply to topical GHK-Cu, but even with injectables, the lack of serious adverse events in animal subjects points to a general tolerability regardless of the route of administration

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Poor bioavailability also leads to under-delivery of key nutrients, forcing the body to compensate under inflammatory conditions