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Unlike stops of exposure, they don't simply double or halve, but instead, depend on the f ratio

In practice, and in view of clonazepams adverseeffect profile, a short, timelimited course of the combination during the initial 4 weeks may be considered when rapid quality of life improvement is prioritized, whereas liquid NAC monotherapy is likely sufficient over an 8week horizon for patients for whom minimizing benzodiazepine exposure is preferred

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The structure represents the covalent acyl-enzyme intermediate, which cannot be resolved by a water molecule as nucleophile in this case (Supplementary Fig