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Others showed that accumulation of A-induced oxidative stress in APOE4 leads to the deregulation of the TP53 gene, and in addition to its role in cancer p53 protein (encoded by a TP53 gene) can be involved in cell death in AD patients, with upregulation at the early stages of the disease and downregulation during neurodegeneration (445)

Moreover, drugs that effectively modulate the actions of opioids in order to improve their safety and analgesic profile are lacking

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And the drugs were just not the correct solution

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