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In mammalians, a long-chain endopolyphosphatase was purified from rat and bovine brain (Kumble and Kornberg, 1996), a human metastasis regulator protein H-prune was identified as a short-chain specific exopolyphosphatase (Tammenkoski et al., 2008), and mammalian intestinal alkaline phosphatase was characterized as a very active exopolyphosphatase (Lorenz and Schroder, 2001)

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