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In fact, in zinc deficient-obesity, leptin rise promoted the increase in macrophage infiltration in adipose tissue of mice fed a high-fat diet (108)

10.1002/ana.1001

Importantly, distinctions must be drawn between hereditary CRC syndromes, sporadic CRC (arising through the adenomacarcinoma sequence), and inflammatory bowel disease (IBD)-associated CRC, as each clinical setting may involve distinct pathways influenced by vitamin D status, perhaps in different ways [54]