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However, PD has a prodromal phase that lasts for decades, resulting in a high possibility of early misdiagnosis (Tolosa et al., 2021)

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Lastly, while antibiotics can improve NDD-related outcomes (e.g., reduce neuroinflammation, reduce amyloid and tau depositions, regulate cholinergic transmission), they have substantial side effects (e.g., antibiotics-associated diarrhea) and lead to gut dysbiosis, which question their use, especially as a long-term intervention, for the management of gut microbiota changes in NDDs (90)

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