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Hydroxyoctadecadienoic acid and oxidatively modified peroxiredoxins in the blood of Alzheimers disease patients and their potential as biomarkers

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The DNA-binding protein inhibitors Id2 and Id4 showed decreased expression during OPC differentiation in mice, which was correlated with hypermethylation of their promoter regions, suggesting a role for DNA methylation in the silencing of these genes to allow the expression of myelin genes during differentiation [104]

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4-HNE protein adducts were detected by an anti 4-HNE protein adduct antibody (1:2000, AB5605, Millipore) in Tris-buffer saline with 5% skim milk, and ECL (GE Healthcare)