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Regulation of TCA Cycle Integration Once -Ketoglutarate (-KG) is generated from glutamine metabolism, it enters the TCA cycle

doi: 10.1038/s41586-020-2922-4 35 KimNKimHKLeeKHongYChoJHChoiJWet al

The specific vulnerability of tumor cells leveraging the aberrant NADPH-synthesis pathways can be exploited to induce cell death under various cellular stresses

It has a beneficial effect for cystic acne or even the occasional breakout, hyper pigmentation, age spots, sun spots, wrinkles, acne, and even melasma