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PCR confirmed that the GR gene (1356 bp) had been replaced with a kanamycin resistance cassette (816 bp), and western blot analyses confirmed that the GR protein was no longer expressed in the mutant strain (Figures 1B and C)

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HDAC (SIRT1) activation can exert therapeutic effects on age-related diseases such as AD by targeting H3K9 acetylation (Cui et al., 2022)

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TGF- is involved in regulating a variety of aspects of host defence to injury

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10.1006/nbdi.1999.0240 Neurobiol

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