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Although both DHLA and LA have been found inside cells after administration, most intracellular DHLA probably exists as mixed disulfides with various cysteine residues from cytosolic and mitochondrial proteins

Pediatrics (2012) 129:e82741.10.1542/peds.2011-3552 10 IwasakiAMedzhitovR

IM injection accelerates absorption, creating a sharper peak plasma concentration that may amplify side effects (nausea, flushing) without reducing injection pain

For both of these variables, the combined treatment of semaglutide and cagrilintide were shown to be more effective than either peptide treatment alone