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This is particularly evident in asthma, in which mitochondrial dysfunction leads to increased ROS production, reduced ATP synthase activity, and abnormal calcium homeostasis, all of which exacerbate airway inflammation and remodeling [112, 113]

We note that much of the literature performs experiments at doses that are likely to induce the non-p53-related effects of the drug in non-isogenic cell lines bearing different p53 status

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In skeletal muscle, resveratrol reduces insulin resistance through various mechanisms, including alterations in metabolism and lipid buildup