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Tables 1 and 2 summarize passive membrane diffusion and active transport membrane permeability, respectively, for select small molecule NNMT inhibitors for which structure activity relationships had been previously developed.[17] 1-MNA, a product inhibitor of NNMT[12, 24, 25] exhibited no passive permeability (Table 1)

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Cell culture studies show stimulation of beta-3 adrenergic receptors in adipocytes, increasing fat oxidation while inhibiting lipogenesis through acetyl CoA carboxylase blockade