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Nat Rev Drug Discov 5:387398

, 103 , 598-605, Ihida-Stansbury, K., Ames, J., Chokshi, M., Aiad, N., Sanyal, S., et al

PET imaging reveals microglia activation in the SN before motor symptoms appear, while peripheral immune cells (e.g., CD8 + T cells and monocytes) can infiltrate the central nervous system through compromised BBB (63)