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Whether parkin has a direct, negative effect on GR activity, such as through physical binding or, possibly through a form of ubiquitylation not yet detected by us [45], or an indirect effect via the redox state of cellular metabolites (e.g., the ratio of NADP + :NADPH/H + ), remains to be elucidated

In ob/ob mice, zinc supplementation markedly attenuates glucose-induced insulin secretion and lessens fasting plasma glucose levels (107)

Two independent reviewers conducted the selection process to ensure consistency, with any discrepancies resolved through discussion

Male C57BL/6 mice, aged 810 weeks and weighing between 20-28 g, were housed under controlled conditions (22C 2C, 12-hour light/dark cycle) and provided with ad libitum access to food and water

References 1.Imperato-McGinley J, Zhu YS