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In addition, it is noteworthy that several foundational studies have reported alterations in microglial gene expression, plausibly reflecting DAM-like phenotypes, in both aging and AD models of mice and humans (Colangelo et al., 2002

Propionate, the three-carbon homologue of acetate, can also modify histones, but its metabolic supply lines are more restricted, and less is known about its significance in the heart

A single change in the aptamer of the Lactiplantibacillus plantarum rib operon riboswitch severely impairs its regulatory activity and leads to a vitamin B2- overproducing phenotype

Its free radical-scavenging abilities make vitamin E helpful for cardiovascular health, cancer protection, neurological health (including slowing the progression of Alzheimers disease), and any situations where oxidative stress increases (such as during pregnancy)

It can also be targeted in IBD treatment through the use of antioxidants, including vitamin C, vitamin E, glutathione, and N-acetylcysteine