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Sanguigno L, Guida N, Anzilotti S, Cuomo O, Mascolo L, Serani A, Brancaccio P, Pennacchio G, Licastro E, Pignataro G, Molinaro P, Annunziato L, Formisano L (2023) Stroke by inducing HDAC9-dependent deacetylation of HIF-1 and Sp1, promotes TfR1 transcription and GPX4 reduction, thus determining ferroptotic neuronal death

doi: 10.1038/srep31006 167 ChangYRyuSZhangYSonHJKimJ-YChoJet al

Published in Nature, the study found that Lipofer reversed #irondeficiency within 14 days and maintained #guthealth, with none of the irritation or inflammation associated with standard iron salts such as ferrous sulfate

The relationship between intracellular GSH level and proteasome inhibition-induced apoptosis still remains to be defined

However, the act of doing so has a downside: it involves the continuous, insidious production of toxic molecules called free radicals or reactive oxygen species (ROS)