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ACSL4-Mediated ferroptosis and its potential role in central nervous system diseases and injuries

As it was recently suggested, GSH depletion could be the Trojan horse of COVID-19 severity and mortality and elevating GSH levels in tissues may decrease COVID-19 severity and mortality rates (Khanfar and Al Qaroot, 2020)

Such damage can be further exacerbated by neutrophil activation at the injury site

Figure 1 3 Typing and diagnosis of diabetic cardiomyopathy and its pathogenesis 3.1 Typing and diagnostic criteria of diabetic cardiomyopathy The histological features of DCM include myocardial collagen deposition, myocardial hypertrophy, and fibrosis ( The minimum diagnostic criteria for DCM include LV diastolic dysfunction and/or reduced LV ejection fraction (LVEF), LV hypertrophy, and interstitial fibrosis and can be divided into three stages: early, advanced, and end

Enhancements of caspase-3 and poly-(ADP-ribose) polymerase PARP levels and a reduction in the level of the Bcl2 protein in brain and liver tissues have been reported following exposure to D-galactose [5, 6, 40]