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The finding that plants have a plastidial redox system (TRX-like 2.2-Cys PRX) capable of oxidizing enzymes in the dark challenges the conventional role of thioredoxins (TRXs), which typically activate enzymes in the light by breaking disulfide bridges

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We also observed upregulation of mesenchymal markers ( VIM and TWIST ) and downregulation of epithelial markers ( CDH1 , CLDN7 and TJP3 , Figures 2F, G ) , consistent with earlier observations in other persister cell models ( Figure 2 CRC Persister Cells Are Vulnerable to Ferroptosis To effectively eliminate CRC DTP cells, we sought to identify therapeutic vulnerabilities in persister cells that are absent in parental and regrown cells

PMID 17869078