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Netea et al., 2020

Estradiol increases stress-induced activation at all levels of the HPA axis, elevating corticotropin-releasing hormone (CRH) and AVP expression in the PVN, POMC mRNA in the pituitary, and ACTH sensitivity in the adrenal glands 80

ANCOVA analysis was performed and revealed similar results to the previously mentioned findings when controlled for IFG/diabetes conditions at the time of screening

The endothelium layer of our arteries produce nitric oxide, which helps relax narrowed blood vessels and increases oxygen and blood flow