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J Clin Invest 2003

Formation of the DSF-copper (CuDSF) complex inhibits the chymotrypsin-like activity of the purified 20S or 26S proteasome in breast cancer cells (MDA-MB-231) (MCF10DCIS.com breast cells, but not in normal MCF-10A breast cells (Skrott et al., 2017

However, the ability to use very high doses of small molecule antioxidants like vitamin E for extended periods of times may be limited by the toxicity of these high doses (392)

However, despite not being formally approved for this purpose, Holey Tox has proven to be an effective method for treating chronic anal fissures and related conditions