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Suggested mechanisms include an imbalance in energy metabolism due to tumor growth, infection, fever, or surgery, malnutrition caused by anorexia, nausea, or vomiting, and an increase in the abnormal production of substances that impair metabolic homeostasis, such as cytokines and proteolysis-inducing factors (2)

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Mechanistic Research Perspective Ghrelin receptor (GHS-R) activation analysis Growth hormone release signaling pathway research Endocrine feedback loop investigation Ligand-receptor interaction studies Intracellular signal transduction pathway modeling Primary Research Applications Growth Hormone Release Mechanism Studies: GHRP-2 is widely used to investigate growth hormone secretion dynamics, receptor activation thresholds, and endocrine pathway responses