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Maternal RPM supplementation, utilizing two different products available in the market (Smartamine M or MetaSmart) during the last 21 days of gestation, promoted a reduction in plasma positive acute-phase proteins, accompanied by a decrease in plasma IL-6 after calving, indicating a reduction in proinflammatory responses (Osorio et al., 2014b)

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First, more human cell lines, including HeLa and A549 cells, were used to confirm the increase in p62 and LC3-II by ORF3a expression (Supplementary Fig