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Theoretical risks of sustained angiogenic stimulation (promoting vascular supply to undetected pathological tissue) grow proportionally with the duration of use, as cumulative VEGF upregulation exceeds the controlled, injury-localized window intended by short-cycle research protocols

doi: 10.3390/ijms23073842 26

Restored PI3K/Akt signaling and increased GLUT1/GLUT3 expression ( ameliorated memory deficits, reduced amyloid burden, improved gut microbiota composition, reduced pro-inflammatory markers (IL-6, IL-1), and enhanced antioxidative enzymes (SOD, IL-4) ( TABLE 4 Key findings from in vivo studies with APP transgenic mice